Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone markers in clinical practice.

J C Souberbielle1, C Cormier, C Kindermans

  • 1Laboratoire de Physiologie, Hôpital Necker-Enfants Malades, Paris, France.

Current Opinion in Rheumatology
|July 20, 1999
PubMed
Summary

Biologic bone turnover markers show potential for predicting bone loss and treatment response in individuals, but clinical use is limited by biologic variability. Further research is needed to establish their role in patient care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Specifications and functional impact of a self-triggered grasp neuroprosthesis developed to restore prehension in hemiparetic post-stroke subjects.

Biomedical engineering online·2024
Same author

Multiple brown tumors: a bone complication due to long-term untreated pseudohypoparathyroidism.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2023
Same author

Severe hypercalcemia complicating granulomatous slack skin disease: an exceptional case.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Pregnancy-related fractures: a retrospective study of a French cohort of 52 patients and review of the literature.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017
Same author

How the reference values for serum parathyroid hormone concentration are (or should be) established?

Journal of endocrinological investigation·2016
Same author

CYP24A1 Mutations in a Cohort of Hypercalcemic Patients: Evidence for a Recessive Trait.

The Journal of clinical endocrinology and metabolism·2015

Area of Science:

  • Biochemistry
  • Endocrinology
  • Orthopedics

Background:

  • Biologic indices of bone turnover are established research tools.
  • Their clinical utility in individual patient management is debated due to significant biologic variability.

Purpose of the Study:

  • To evaluate the clinical utility of bone turnover markers.
  • To assess their role in predicting bone loss and treatment response.

Main Methods:

  • Review of current bone markers including serum osteocalcin, bone-specific alkaline phosphatase, N-terminal propeptide of type 1 procollagen, and urinary crosslinks/telopeptides.
  • Discussion of new serum C-telopeptide and N-telopeptide assays.

Main Results:

  • Bone markers offer limited diagnostic value for osteoporosis.
  • They can predict bone loss rates in menopausal women and response to antiresorptive therapies.
  • Increased bone turnover may independently predict fracture risk.

Conclusions:

  • Bone turnover markers have potential in predicting bone loss and treatment response but require further validation for routine clinical use.
  • Cost-benefit analyses and patient outcome evaluations are necessary before widespread adoption for patient care optimization.

Related Experiment Videos