Related Experiment Videos
In vitro activity of penicillins against anaerobes
Antimicrobial Agents and Chemotherapy
|April 1, 1975
Abstract:
The in vitro susceptibility of 162 anaerobic isolates from clinical material were tested to pencillin G, BL-P1654, and carbenicillin. Penicillin G and BL-P1654 showed good activity against Bacteroides fragilis, but only 60% of strains were susceptible to carbenicillin at achievable blood levels (128 mug/ml).
Insights
Penicillin G and BL-P1654 demonstrate effective in vitro activity against Bacteroides fragilis. However, carbenicillin showed limited susceptibility in anaerobic isolates at achievable blood levels.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Anaerobic bacteria are significant pathogens in various infections.
- Antimicrobial resistance in anaerobic bacteria poses a clinical challenge.
Purpose of the Study:
- To evaluate the in vitro antimicrobial susceptibility of clinical anaerobic isolates.
- To compare the activity of penicillin G, BL-P1654, and carbenicillin against these isolates.
Main Methods:
- Testing of 162 anaerobic bacterial isolates from clinical specimens.
- In vitro susceptibility testing using penicillin G, BL-P1654, and carbenicillin.
Main Results:
- Penicillin G and BL-P1654 exhibited good in vitro activity against Bacteroides fragilis.
- Only 60% of Bacteroides fragilis strains were susceptible to carbenicillin at 128 µg/ml.
Conclusions:
- Penicillin G and BL-P1654 are potentially effective agents against Bacteroides fragilis.
- Carbenicillin demonstrates limited efficacy against Bacteroides fragilis at tested concentrations.