[Renal oncocytomatosis]

Area of Science:

• Nephrology
• Oncology
• Pathology

Background:

• Multiple and bilateral renal oncocytomas are exceptionally rare, with only ten cases documented previously.
• The term 'oncocytomatosis' describes cases with multiple and bilateral oncocytomas and microoncocytomas.

Observation:

• A rare case of renal oncocytomatosis was identified during an autopsy.
• The autopsy also revealed an adrenal adenoma, a pheochromocytoma, and thoracic cicatrices in a patient with a history of resected lung carcinoma.
• Oncocytic epithelial cells transitioning into microoncocytomas were observed in the distal renal tubules.

Findings:

• Immunohistochemical analysis showed that both microoncocytomas and main oncocytomas were CD 10 negative.
• Comparative genomic hybridization (CGH) analysis did not reveal common cytogenetic alterations across the different tumors.
• These findings support the hypothesis that renal oncocytomas arise from oncocytically transformed distal tubular epithelium.

Implications:

• This case contributes to the understanding of the pathogenesis of renal oncocytomas.
• The study highlights the rare coexistence of renal oncocytomatosis with other tumors, a phenomenon not previously described.
• The findings underscore the importance of comprehensive histopathological examination in identifying rare tumor presentations.