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[Renal oncocytomatosis].

S Ulrich1, U Wagner, H Moch

  • 1Kantonales Institut für Pathologie, Liestal.

Der Pathologe
|July 21, 1999
PubMed
Summary
This summary is machine-generated.

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This case report details renal oncocytomatosis, a rare condition involving multiple kidney tumors. The findings suggest oncocytomas originate from transformed distal tubular epithelium, a novel insight into tumor development.

Area of Science:

  • Nephrology
  • Oncology
  • Pathology

Background:

  • Multiple and bilateral renal oncocytomas are exceptionally rare, with only ten cases documented previously.
  • The term 'oncocytomatosis' describes cases with multiple and bilateral oncocytomas and microoncocytomas.

Observation:

  • A rare case of renal oncocytomatosis was identified during an autopsy.
  • The autopsy also revealed an adrenal adenoma, a pheochromocytoma, and thoracic cicatrices in a patient with a history of resected lung carcinoma.
  • Oncocytic epithelial cells transitioning into microoncocytomas were observed in the distal renal tubules.

Findings:

  • Immunohistochemical analysis showed that both microoncocytomas and main oncocytomas were CD 10 negative.
  • Comparative genomic hybridization (CGH) analysis did not reveal common cytogenetic alterations across the different tumors.

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  • These findings support the hypothesis that renal oncocytomas arise from oncocytically transformed distal tubular epithelium.

    • Implications:

    • This case contributes to the understanding of the pathogenesis of renal oncocytomas.
    • The study highlights the rare coexistence of renal oncocytomatosis with other tumors, a phenomenon not previously described.
    • The findings underscore the importance of comprehensive histopathological examination in identifying rare tumor presentations.