Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Detecting QTLs for uni- and bipolar disorder using a variance component method.

P M Visscher1, C S Haley, S C Heath

  • 1University of Edinburgh, Division of Biological Sciences, UK. peter.visscher@ed.ac.uk

Psychiatric Genetics
|July 21, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptation of the polarimetric multi-spectral Aerosol Limb Imager for high altitude aircraft and satellite observations.

Applied optics·2021
Same author

Advance-care-planning and end-of-life discussions in the perioperative period: a review of healthcare professionals' knowledge, attitudes, and training.

British journal of anaesthesia·2018
Same author

Embracing polygenicity: a review of methods and tools for psychiatric genetics research.

Psychological medicine·2017
Same author

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.

Molecular psychiatry·2017
Same author

A DNA methylation biomarker of alcohol consumption.

Molecular psychiatry·2016
Same author

Leveraging genetically simple traits to identify small-effect variants for complex phenotypes.

BMC genomics·2016

This study identified a significant genetic region on chromosome 4 linked to bipolar disorder and unipolar disorder in a Scottish family. This quantitative trait locus (QTL) explains a substantial portion of the disorder

Area of Science:

  • Genetics
  • Psychiatry
  • Statistical genomics

Background:

  • Previous studies suggested a linkage for bipolar disorder on chromosome 4.
  • Extended families are valuable for genetic linkage studies.

Purpose of the Study:

  • To analyze unipolar and bipolar disorder in a large Scottish extended family using a robust variance component method.
  • To identify specific genetic loci associated with mood disorders.

Main Methods:

  • Variance component analysis incorporating identity-by-descent (IBD) coefficients.
  • Utilized a Monte Carlo Markov Chain algorithm for IBD estimation.
  • Applied residual maximum likelihood (REML) to partition variance.

Main Results:

Related Experiment Videos

  • A significant linkage region (maximum LOD score of 5.9) was identified on chromosome 4, spanning approximately 10 cM.
  • This region, associated with either unipolar or bipolar disorder, explained about 25% of the total trait variation.
  • Eleven markers on chromosome 4 were analyzed.

    • Conclusions:

    • A putative quantitative trait locus (QTL) for mood disorders is located on chromosome 4.
    • This finding supports the genetic basis of unipolar and bipolar disorder and provides a target for further research.