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QSAR study on 1-benzyl-4[w(substituted phthalimido)alkyl]piperidines:acetyl cholinesterase inhibitors
A K Srivastava1, A Khare, S Agrawal
1Chemistry Department, University of Allahabad, India.
Indian Journal of Biochemistry & Biophysics
|July 21, 1999
Abstract:
QSAR studies on a series of 18 piperidine derivatives, which act as acetyl cholinesterase (AchE) inhibitors, have been performed using van der Waals volume (V omega) and topochemical index (tau). Significant correlations have been obtained, which make it clear that AchE inhibition activity is controlled dominantly by topo chemical index.