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Chronic Aspergillus sp. meningitis successfully treated with fluconazole. Case report
W M Mariushi1, W O Arruda, M H Tsubouchi
1Unidade de Ciências Neurológicas, Hospital das Nações, Brasil.
Arquivos De Neuro-Psiquiatria
|July 21, 1999
Abstract:
We a case of chronic Aspergillus sp. meningitis in a healthy 43-year-old woman successfully treated with fluconazole given orally (300 ms/day). The diagnosis was made by detection of anti-aspergillus antibodies and positive culture to Aspergillus sp. in the cerebrospinal fluid.
Insights
This case study shows successful treatment of chronic Aspergillus meningitis in a healthy woman using oral fluconazole. Diagnosis involved detecting anti-Aspergillus antibodies and cerebrospinal fluid cultures.
Area of Science:
- Mycology
- Infectious Diseases
- Neurology
Background:
- Chronic meningitis can be challenging to diagnose and treat.
- Aspergillus species are opportunistic fungal pathogens that can cause invasive infections.
Observation:
- A 43-year-old, previously healthy woman presented with symptoms suggestive of chronic meningitis.
- Cerebrospinal fluid analysis revealed a positive culture for Aspergillus species and elevated anti-Aspergillus antibodies.
Findings:
- The patient was successfully treated with oral fluconazole at a dosage of 300 mg/day.
- This indicates fluconazole's efficacy in managing Aspergillus-related central nervous system infections.
Implications:
- This case highlights the importance of considering fungal meningitis in the differential diagnosis of chronic meningitis.
- Successful treatment with oral fluconazole suggests a potential therapeutic option for similar cases, even in immunocompetent individuals.