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Related Experiment Videos

Apolipoprotein E polymorphism and renal disease.

H Oda1, N Yorioka, C Ueda

  • 1Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan. yasuaya1@urban.ne.jp

Kidney International. Supplement
|July 21, 1999
PubMed
Summary
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Apolipoprotein E (apoE) gene variations, specifically apoE2, may predispose Japanese individuals to end-stage renal disease (ESRD). The impact of apoE phenotypes on lipid profiles in renal patients differs from the general population.

Area of Science:

  • Genetics
  • Nephrology
  • Biochemistry

Background:

  • Lipid abnormalities are common in end-stage renal disease (ESRD) and may accelerate kidney disease progression.
  • Apolipoprotein E (apoE) plays a crucial role in lipoprotein metabolism, with variations in apoE phenotypes influencing this process.
  • Allele frequencies of apoE differ across racial groups, necessitating population-specific studies.

Purpose of the Study:

  • To investigate the allele frequencies of apolipoprotein E (apoE) phenotypes in Japanese patients with renal disease.
  • To evaluate the influence of apoE polymorphism on the lipid profiles of these patients.

Main Methods:

  • Apolipoprotein E (apoE) phenotypes were determined in 592 Japanese renal disease patients using isoelectric focusing and Western blotting.

Related Experiment Videos

  • Allele frequencies and phenotype distributions were calculated using the gene-counting method.
  • Serum lipid parameters were measured after a minimum 12-hour fast.

    • Main Results:

    • Glomerulonephritis patients with proteinuria showed higher apoE2 and apoE4 allele frequencies and lower apoE3 frequency compared to controls.
    • End-stage renal disease (ESRD) patients exhibited higher apoE2 and lower apoE4 allele frequencies than controls.
    • The effect of apoE polymorphism on lipid profiles in renal patients (glomerulonephritis, hemodialysis, CAPD) deviated from typical expectations.

    Conclusions:

    • Elevated apoE2 frequency in ESRD patients suggests a potential genetic predisposition in the Japanese population.
    • The influence of apoE2 and apoE4 on lipid profiles in renal disease patients is distinct from that observed in the general population.