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Probucol suppresses ICAM-1 expression in rat mesangial cells: possible role of IL-1
T Sugiura1, A Wada, T Moriyama
1First Department of Medicine, Osaka University School of Medicine, Osaka National Hospital, Japan. sugiura@medone.med.osaka-u.ac.jp
Abstract:
Interleukin-1 (IL-1) participates in the progression of glomerulonephritis by up-regulating intercellular adhesion molecule-1 (ICAM-1) expression in experimental glomerulonephritis. Probucol, an anti-hyperlipidemic agent, ameliorates some types of glomerulonephritis regardless of serum cholesterol levels, and is also reported to inhibit IL-1 release from macrophages in atherosclerotic lesions. However, little is known about the mechanism of this favorable action on glomerular injury. We examined whether or not probucol inhibits ICAM-1 expression by suppression of IL-1 action in cultured rat mesangial cells. In this brief report, we review the actions of probucol on IL-1 secretion and discuss the possible mechanism by which probucol may suppress the glomerular injury.