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Diffuse central nervous system lupus involving white matter, basal ganglia, thalami and brainstem
M Shibata1, T Kibe, S Fujimoto
1Department of Pediatric, Nagoya City University Medical School, Nagoya, Japan.
Brain & Development
|July 21, 1999
Abstract:
We described an 11-year-old girl with acute central nervous system lupus showing diffuse lesions. She developed generalized convulsions followed by prolonged coma, and her psychomotor ability recovered fully after 3 months of steroid therapy. Cranial magnetic resonance imaging (MRI) showed high signal intensity in the cerebral deep white matter, bilateral basal ganglia, thalami, and brainstem on T2-weighted image. These lesions resolved over 1 month with residual atrophic change in the heads of the caudate nucleus on MRI. Acute SLE leukoencephalopathy may be recognized as a subtype of CNS lupus.