Sentence processing in Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative condition that is associated with the depletion of dopamine (DA)-containing neurons in specific brain regions. This article reviews one consequence of this defect-sentence comprehension difficulty in nondemented patients with PD. The first section describes the pattern of cognitive deficits seen in patients with PD, focusing specifically on their difficulties with language processing. Subsequent sections relate the profile of cognitive impairments in PD to studies investigating compromised DA metabolism in fronto-striatal brain regions. The findings suggest that the sentence comprehension deficit in PD is due in large part to limitations in the strategic distribution of cognitive resources such as selective attention that contribute to the processing of complex material. The physiological basis for this deficit appears to be associated with the disruption of a fronto-striatal cerebral network that is compromised following degradation of the DA projection system.