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[Early decrease in diastolic function in young type I diabetic patients as an initial manifestation of diabetic

C M Schannwell1, F C Schoebel, S Heggen

  • 1Medizinische Klinik, Heinrich-Heine-Universität Düsseldorf.

Zeitschrift Fur Kardiologie
|July 22, 1999
PubMed
Summary

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Young patients with insulin-dependent diabetes mellitus (IDDM) exhibit diastolic dysfunction, even with normal systolic function. Echocardiography can detect this early sign of diabetic cardiomyopathy.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Myocardial manifestation in insulin-dependent diabetes mellitus (IDDM) is crucial for prognosis.
  • Diabetic cardiac complications often mask early myocardial changes.
  • Early detection of cardiac issues in young IDDM patients is vital.

Purpose of the Study:

  • To investigate diastolic left ventricular (LV) dysfunction in young, asymptomatic IDDM patients.
  • To determine if normal systolic LV function in IDDM patients coexists with diastolic dysfunction.
  • To identify early cardiac manifestations in IDDM.

Main Methods:

  • Echocardiography performed on 92 IDDM patients and 50 controls.
  • M-mode echocardiography for morphological and systolic parameters (ejection fraction).

Related Experiment Videos

  • Doppler indices measured: diastolic flow velocities (VE, VA), E/A ratio, deceleration time (DT), isovolumetric relaxation time (IVRT).

    • Main Results:

    • IDDM patients showed normal LV dimensions and systolic function.
    • Significant diastolic dysfunction observed: reduced early diastolic filling (VE) and E/A ratio.
    • Increased atrial filling (VA), prolonged IVRT, and extended DT in IDDM patients.

    Conclusions:

    • Young IDDM patients with normal systolic function exhibit diastolic dysfunction.
    • Diastolic dysfunction serves as an early marker for diabetic cardiomyopathy.
    • Echocardiography is a valuable tool for monitoring diabetic cardiomyopathy progression.