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[Mast cell hyperplasia in bone oxalosis]
M E Duarte1, A L Peixoto, A Pacheco
1Departamento de Patologia da Faculdade de Medicina da Universidade Federal Fluminense-Hospital Universitário Antonio Pedro, Rio de Janeiro.
Revista Da Associacao Medica Brasileira (1992)
|July 22, 1999
Summary
Bone marrow mast cell hyperplasia is significantly elevated in patients with oxalosis. This increase is specific to oxalosis and not chronic renal failure, potentially contributing to bone marrow fibrosis.
Area of Science:
- Histomorphometry
- Hematology
- Nephrology
Context:
- Chronic renal failure (CRF) can lead to complications like oxalosis.
- Bone marrow changes are associated with systemic diseases.
- Mast cells play a role in inflammatory and fibrotic processes.
Purpose:
- To investigate bone marrow mast cell hyperplasia in patients with CRF and oxalosis.
- To differentiate mast cell changes related to oxalosis versus CRF.
Summary:
- Histomorphometric analysis of iliac crest bone biopsies was performed on three groups: CRF with oxalosis, CRF alone, and controls.
- Mast cell counts (cells/mm²) were significantly higher in patients with oxalosis (32.67 ± 9.59) compared to CRF (20.84 ± 5.04) and controls (3.26 ± 1.03).
Impact:
- Oxalosis of bone is associated with a substantial increase in bone marrow mast cells.
- This mast cell increase is specific to oxalosis, not a general response to CRF or fibrosis.
- Mast cell accumulation may contribute to bone marrow fibrosis in oxalosis.