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[Mast cell hyperplasia in bone oxalosis]
M E Duarte1, A L Peixoto, A Pacheco
1Departamento de Patologia da Faculdade de Medicina da Universidade Federal Fluminense-Hospital Universitário Antonio Pedro, Rio de Janeiro.
Insights
Bone marrow mast cell hyperplasia is significantly elevated in patients with oxalosis. This increase is specific to oxalosis and not chronic renal failure, potentially contributing to bone marrow fibrosis.
Area of Science:
- Histomorphometry
- Hematology
- Nephrology
Context:
- Chronic renal failure (CRF) can lead to complications like oxalosis.
- Bone marrow changes are associated with systemic diseases.
- Mast cells play a role in inflammatory and fibrotic processes.
Purpose:
- To investigate bone marrow mast cell hyperplasia in patients with CRF and oxalosis.
- To differentiate mast cell changes related to oxalosis versus CRF.
Summary:
- Histomorphometric analysis of iliac crest bone biopsies was performed on three groups: CRF with oxalosis, CRF alone, and controls.
- Mast cell counts (cells/mm²) were significantly higher in patients with oxalosis (32.67 ± 9.59) compared to CRF (20.84 ± 5.04) and controls (3.26 ± 1.03).
Impact:
- Oxalosis of bone is associated with a substantial increase in bone marrow mast cells.
- This mast cell increase is specific to oxalosis, not a general response to CRF or fibrosis.
- Mast cell accumulation may contribute to bone marrow fibrosis in oxalosis.
Background:
To assess by means of histomorphometry the incidence of bone marrow mast cell hyperplasia in patients with chronic renal failure and oxalosis.
Material And Methods:
Eighteen individuals were assigned to three groups: 6 (4 males and 2 females, aged 26.31 +/- 2.5 yrs) had chronic renal failure (CRF) and oxalosis of bone; 6 (1 male and 5 females aged 22.1 +/- 3.56 yrs) had CRF and 6 normal (5 males and 1 female aged 23 +/- 2.78 yrs) individuals entered the control group. Quantitative histologic assessments were completed in undecalcified sections of plastic embedded iliac crest bone biopsies stained by the Toluidine Blue method for identification of mast cells. The number of mast cells (cell/mm2 tissue area, x +/- sd) was determined by a semiautomatic image-analyzing system.
Results:
The number of mast cells was greater in patients with oxalosis of bone, 32.67 +/- 9.59, than in patients with CRF (20.84 +/- 5.04, p < 0.05) and than in the control group (3.26 +/- 1.03, p < 0.001).
Conclusions:
Oxalosis of bone is associated with substantial increases in the number of mast cells in the bone marrow. Such a change is not related to chronic renal failure per se and does not appear to represent a non-specific response to bone marrow fibrosis. Mast cell accumulation may contribute to the development of bone marrow fibrosis seen in this disorder.