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Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice
1Department of Behavioral Neuroscience and the Portland Alcohol Research Center, Oregon Health Sciences University, 97201-3098, USA.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|July 22, 1999
Abstract:
DBA/2J mice repeatedly exposed to ethanol (2 g/kg, i.p. every 48 h for 8 days) exhibit sensitization to the locomotor stimulant effects of ethanol. Pretreatment with the NMDA receptor antagonist dizocilpine (0.2-0.3 mg/kg, i.p.) completely prevents the development of sensitization. Thus, NMDA receptors appear to play an important role in behavioural sensitization to ethanol.