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Presinusoidal portal hypertension does not affect hepatic artery resistance index
1Department of Radiology, Türkiye Yüksek Ihtisas Hospital, TR-06100, Sihhiye, Ankara, Turkey.
Insights
Hepatic artery resistance index (RI) is lower in presinusoidal portal hypertension than sinusoidal portal hypertension. This finding aids in differentiating these conditions, though some overlap exists.
Area of Science:
- Radiology
- Hepatology
- Vascular Medicine
Background:
- Portal hypertension is a serious condition affecting liver function.
- Distinguishing between presinusoidal and sinusoidal portal hypertension is crucial for effective management.
- Hepatic artery resistance index (RI) is a potential biomarker for assessing portal hemodynamics.
Purpose of the Study:
- To determine the mean hepatic artery RI in presinusoidal portal hypertension.
- To compare hepatic artery RI values between presinusoidal and sinusoidal portal hypertension.
- To evaluate the utility of hepatic artery RI in differentiating these two conditions.
Main Methods:
- Duplex Doppler ultrasound was used to examine hepatic artery RIs.
- The study included 11 patients with presinusoidal portal hypertension, 12 with sinusoidal portal hypertension, and 16 healthy controls.
- Statistical analysis was performed to compare mean RI values across the groups.
Main Results:
- Mean hepatic artery RI was significantly lower in presinusoidal portal hypertension (0.63 ± 0.06) compared to sinusoidal portal hypertension (0.73 ± 0.03).
- No significant difference was found between presinusoidal portal hypertension and controls (0.67 ± 0.05).
- Mean hepatic artery RI was significantly higher in sinusoidal portal hypertension than in controls.
Conclusions:
- Hepatic arterial resistance remains unchanged in presinusoidal portal hypertension but increases in sinusoidal portal hypertension.
- Hepatic artery RI can help differentiate between presinusoidal and sinusoidal portal hypertension.
- Overlapping RI values may present challenges in definitive differentiation.
Abstract:
We aimed to determine the mean hepatic artery resistance index (RI) in presinusoidal portal hypertension and to compare the values with those in sinusoidal portal hypertension. The hepatic artery RIs of 11 patients with presinusoidal portal hypertension, 12 patients with sinusoidal portal hypertension and 16 healthy subjects were examined with duplex Doppler ultrasound. Mean hepatic artery RIs of three groups were compared. In patients with presinusoidal portal hypertension, mean RI in the hepatic artery (0.63 +/- 0.06) was significantly lower (p < 0.05) than that in the patients with sinusoidal portal hypertension (0.73 +/- 0.03). There was no significant difference (p > 0.05) in the mean RIs of the hepatic artery between the patients with presinusoidal portal hypertension (0.63 +/- 0.06) and the controls (0.67 +/- 0.05). Mean RI value in patients with sinusoidal portal hypertension (0.73 +/- 0.03) was significantly higher (p < 0.05) than the mean values in the control group (0.67 +/- 0.05). Hepatic arterial resistance does not change in presinusoidal portal hypertension, whereas it increases in sinusoidal portal hypertension. However, there are some overlaps in the RI values which raise difficulties in the differentiation of these two forms of portal hypertension.