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Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation
Y Matsuoka1, M Okazaki, Y Kitamura
1Department of Neurobiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8412, Japan. matsuoka@nki.rfmh.org
Brain Research
|July 23, 1999
Abstract:
Inducible cyclooxygenase (COX-2) was transiently induced in the neurons throughout the entire hippocampus between 6 and 24 h after injection of kainic acid (KA). The induction of COX-2 correlated more closely with the induction of c-Jun than with that of c-Fos. Phosphorylated c-Jun was induced 6-12 h after in the CA3 pyramidal neurons, which undergo apoptosis. Almost all of neurons with phosphorylated c-Jun were colocalized with COX-2. These results suggest that COX-2 and c-Jun phosphorylation may participate in KA-induced neurodegeneration.