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Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
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EXO1 of Saccharomyces cerevisiae functions in mutagenesis during double-strand break repair

S L Holbeck1, J N Strathern

  • 1NCI-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Maryland 21702-1201, USA.

Annals of the New York Academy of Sciences
|July 23, 1999
PubMed
Abstract

No abstract available in PubMed .

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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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