Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bioreactor development for tissue-engineered cartilage.

F Wu1, N Dunkelman, A Peterson

  • 1Advanced Tissue Sciences, Inc., La Jolla, California 92037-1005, USA. flo.wu@advancedtissue.com

Annals of the New York Academy of Sciences
|July 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracting geriatric syndromes from electronic health records: a scoping review.

European geriatric medicine·2026
Same author

Research Letter: Childhood Adversity and Risk of Subsequent Head and Neck Injury: an ABCD Cohort Analysis.

medRxiv : the preprint server for health sciences·2025
Same author

Early detection of antiseizure medication inefficacy using an implantable continuous EEG system and a personalized model: a case study.

Epilepsy & behavior reports·2025
Same author

The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

Tribology letters·2025
Same author

The effect of preoperative carbohydrate loading on patients' anxiety prior to elective caesarean delivery: a randomized controlled trial.

International journal of obstetric anesthesia·2025
Same author

The power and pain of words: how language matters in responding to patients after harm.

Frontiers in health services·2025

Tissue-engineered cartilage, created using chondrocytes on biodegradable scaffolds in a bioreactor, shows promise for repairing cartilage defects. This method allows for controlled development of cartilage for in vivo therapy.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Cartilage defects pose significant challenges for articular surface repair.
  • Current treatments are limited, driving the need for innovative therapeutic strategies.
  • Tissue engineering offers a promising avenue for regenerating functional cartilage.

Purpose of the Study:

  • To demonstrate the synthesis of tissue-engineered articular cartilage using chondrocytes and biodegradable scaffolds.
  • To explore the use of convective-flow bioreactors for cartilage tissue engineering.
  • To discuss bioreactor design considerations for translating research to clinical applications.

Main Methods:

  • Chondrocytes were seeded onto poly-glycolic acid (PGA) biodegradable scaffolds.

Related Experiment Videos

  • Constructs were cultivated within a convective-flow bioreactor system.
  • Biochemical and biomechanical properties were assessed for dimensional control.

    • Main Results:

    • Successful synthesis of tissue-engineered articular cartilage was achieved under convective-flow conditions.
    • The study highlights the ability to manipulate cell-polymer constructs for specific properties.
    • Bioreactor design requirements for research, development, and commercialization were analyzed.

    Conclusions:

    • Convective-flow bioreactor systems enable the synthesis of functional tissue-engineered cartilage.
    • This approach holds potential for in vivo therapy of damaged articular surfaces.
    • Further development of bioreactor technology is crucial for clinical translation.