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Tissue inhibitors of matrix metalloproteinases in cancer
L Blavier1, P Henriet, S Imren
1Department of Pediatrics, Childrens Hospital Los Angeles, University of Southern California 90027, USA.
Annals of the New York Academy of Sciences
|July 23, 1999
Abstract:
Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases (MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity, which affects cell proliferation and survival. The role of these inhibitors in cancer has been the subject of extensive investigations that have examined their biological activity in tumor growth, invasion, metastasis and angiogenesis, as well as their potential use in the diagnosis and treatment of human cancer.