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Determination of unbound drug concentration and protein-drug binding fraction in plasma
1Department of Analytical Chemistry, Shenyang Pharmaceutical University, People's Republic of China.
Biomedical Chromatography : BMC
|July 23, 1999
Abstract:
The aim of this work was to provide a short overview of existing methods for the determination of free drug concentration and protein-drug binding fraction in plasma. Various methods have been described in terms of principles, evaluation of methods, and applications in recent years, with an emphasis on the chromatographic method, i.e. high-performance frontal analysis (HPFA).