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Published on: September 9, 2012
Factor VII deficiency in a mixed breed dog.
R Macpherson1, J Scherer, M L Ross
1Western Animal Clinic, London, Ontario.
Summary
A young dog experienced abnormal bleeding post-surgery due to factor VII deficiency. This inherited coagulation disorder was diagnosed after ruling out acquired causes like vitamin K deficiency.
Area of Science:
- Veterinary Medicine
- Hematology
- Canine Genetics
Background:
- Routine orchectomy is a common surgical procedure in veterinary medicine.
- Coagulation disorders can lead to significant post-operative complications, including excessive bleeding.
- Factor VII deficiency is a rare inherited bleeding disorder affecting multiple species.
Observation:
- A 5-month-old mixed-breed dog presented with abnormal bleeding after a routine orchectomy.
- The bleeding did not respond to vitamin K therapy.
- No plasma coagulation inhibitors were detected in the patient's blood.
Findings:
- The abnormal bleeding was diagnosed as factor VII deficiency.
- The clinical presentation and lack of response to vitamin K suggested an inherited etiology.
- The absence of a detected coagulation inhibitor further supported an inherited factor VII deficiency.
Implications:
- This case highlights the importance of considering inherited coagulation disorders in young animals with unexplained bleeding.
- Accurate diagnosis of factor VII deficiency is crucial for appropriate management and potential genetic counseling.
- Understanding the genetic basis of bleeding disorders in dogs can improve diagnostic and therapeutic strategies.
