Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolutionary game theory and multiple chemical sensitivity.

D B Newlin1

  • 1National Institute on Drug Abuse-Intramural Research Program, Baltimore, Maryland 21224, USA. dnewlin@irp.nida.nih.gov

Toxicology and Industrial Health
|July 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A twin study on sensation seeking, risk taking behavior and marijuana use.

Drug and alcohol dependence·2001
Same author

Family history influence on drug abuse severity and treatment outcome.

Drug and alcohol dependence·2001
Same author

Environmental transmission of DSM-IV substance use disdorders in adoptive and step families.

Alcoholism, clinical and experimental research·2001
Same author

Intravenous cocaine decreases cardiac vagal tone, vagal index (derived in lorenz space), and heart period complexity (approximate entropy) in cocaine abusers.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2000
Same author

Season of birth and substance abuse: findings from a large national sample.

Alcoholism, clinical and experimental research·2000
Same author

Effect of alcohol on vagal regulation of cardiovascular function: contributions of the polyvagal theory to the psychophysiology of alcohol.

Experimental and clinical psychopharmacology·1999
Same journal

The history of the Toxicology Roundtable-75 years of scientific discussion.

Toxicology and industrial health·2026
Same journal

Perfluorooctane sulfonate (PFOS) increases metastatic potential of thyroid cancer cells in correlation with activation of multiple invasion-related signaling proteins.

Toxicology and industrial health·2026
Same journal

Biological and computational evidence of dinotefuran-DNA interactions: A combined <i>in</i> <i>vitro</i> and <i>in</i> <i>silico</i> study.

Toxicology and industrial health·2026
Same journal

Dibromoacetonitrile mediated depression-like behavior in mice and induced HT22 cytotoxicity through the MKP-1/P38 MAPK signaling pathway and the antagonistic effect of N-acetylcysteine.

Toxicology and industrial health·2026
Same journal

Subchronic γ-hexachlorocyclohexane exposure is associated with altered TLR4-linked pulmonary immune responses following endotoxin challenge: Insights from a two-hit mouse model.

Toxicology and industrial health·2026
Same journal

Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.

Toxicology and industrial health·2026
See all related articles

Multiple chemical sensitivity (MCS) may stem from an evolutionary survival response, where the brain

Area of Science:

  • Neuroscience
  • Evolutionary Biology
  • Toxicology

Background:

  • Addictive behaviors can be explained by evolutionary game theory.
  • Multiple Chemical Sensitivity (MCS) involves a heightened stress response to toxicants.

Purpose of the Study:

  • To propose an evolutionary game theory model for Multiple Chemical Sensitivity (MCS).
  • To explain the neurobiological mechanisms underlying MCS and compare them to substance abuse.

Main Methods:

  • Application of evolutionary game theory to MCS.
  • Hypothesizing the role of the cortico-mesolimbic dopamine system in MCS.
  • Discussing an autoshaping/sign-tracking model.

Main Results:

  • MCS patients exhibit neural sensitization in the dopamine system due to a positive feedback loop.

Related Experiment Videos

  • MCS patients perceive toxicants as survival threats, unlike non-MCS individuals who develop tolerance.
  • The model predicts distinct responses between MCS, non-MCS, and substance abusers.

    • Conclusions:

    • MCS may be an overactive survival-defense mechanism.
    • The cortico-mesolimbic dopamine system acts as a survival motivator, not a reward center, in MCS.
    • This theory offers testable predictions for experimental validation.