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A sheep model for temporomandibular joint ankylosis
H Miyamoto1, K Kurita, J Ishimaru
1Department of Dentistry, The University of Adelaid, South Australia, Australia. oral_surgery@dentistry.adelaide.edu.au
Summary
This study developed an animal model for temporomandibular joint (TMJ) ankylosis by surgically altering sheep TMJs. The model rapidly induced fibrous ankylosis, showing potential for future research into TMJ disorders.
Area of Science:
- Oral and Maxillofacial Surgery
- Orthodontics
- Veterinary Medicine
Background:
- Temporomandibular joint (TMJ) ankylosis is a debilitating condition characterized by the fusion of the jaw to the skull.
- Developing reliable animal models is crucial for understanding the pathogenesis and treatment of TMJ ankylosis.
Purpose of the Study:
- To establish a reproducible animal model for studying temporomandibular joint (TMJ) ankylosis.
Main Methods:
- Sheep underwent surgical removal of the temporal and condylar articular surfaces with discectomy in the right TMJ, with the left side serving as a control.
- Histological examination and a scoring system were employed to assess the extent of ankylosis.
- Jaw movement was measured preoperatively and at 3 months post-surgery.
Main Results:
- Operated TMJs showed significant fibrous and cartilage-like tissue ingrowth, leading to reduced jaw movement.
- Histological scores indicated rapid development of ankylosis and calcification.
- While new bone formation occurred, complete bony fusion was not observed within the study period.
Conclusions:
- Surgical alteration of the TMJ articular surfaces and disc effectively induces rapid fibrous ankylosis in an animal model.
- This model provides a valuable platform for investigating the factors contributing to TMJ ankylosis and for evaluating therapeutic interventions.