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Related Experiment Videos

Unclassified endogenous eczema.

A R MacKenzie-Wood1, S Freeman

  • 1Skin & Cancer Foundation Australia, Darlinghurst, NSW.

Contact Dermatitis
|July 23, 1999
PubMed
Summary
This summary is machine-generated.

A significant portion of patients diagnosed with unclassified endogenous eczema may actually have atypical atopic dermatitis. Further investigation revealed many cases improved or resolved over time.

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Intractable eczema often leads to patch testing to rule out contact dermatitis.
  • Patients without contact dermatitis are diagnosed with endogenous eczema.
  • A notable percentage of these patients do not fit established endogenous eczema patterns, termed unclassified endogenous eczema.

Purpose of the Study:

  • To investigate the characteristics and natural history of patients diagnosed with unclassified endogenous eczema.
  • To determine if unclassified endogenous eczema represents a distinct clinical entity or atypical presentations of other conditions.

Main Methods:

  • Retrospective review of patients diagnosed with unclassified endogenous eczema at an Occupational and Contact Dermatitis Clinic since March 1996.
  • Serum IgE levels were measured in a subset of patients.

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  • Telephone follow-up was conducted to assess the long-term outcome of the condition.

    • Main Results:

    • Unclassified endogenous eczema constitutes 8% of patients at the clinic.
    • Elevated IgE levels (>100 IU/ml) were found in 12 out of 34 patients, suggesting a link to atopy.
    • Approximately one-third of patients may have atypical, late-onset atopic dermatitis.
    • Of 31 patients contacted after an average of 2 years, 20 showed improvement or resolution of their eczema.

    Conclusions:

    • Unclassified endogenous eczema is an under-recognized diagnostic category.
    • A significant proportion of these patients may represent atypical atopic dermatitis.
    • Further research is warranted to understand and manage this eczema subtype.