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Long-lasting allergic patch test reactions: a study of patients with positive standard patch tests
G Mancuso1, R M Berdondini, G Cavrini
1Department of Dermatology of Municipal Hospital of Lugo, Ravenna, Italy.
Contact Dermatitis
|July 23, 1999
Summary
Long-lasting allergic patch test reactions (LLAPTR) are common, affecting 17.9% of patients. Sensitivity to Kathon CG, atopy, and strong reactions are key risk factors for LLAPTR.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis
Background:
- Patch testing is crucial for diagnosing allergic contact dermatitis.
- The duration and factors influencing long-lasting allergic patch test reactions (LLAPTR) require further investigation.
Purpose of the Study:
- To determine the duration of patch test reactions.
- To establish the frequency of LLAPTR.
- To identify risk factors associated with LLAPTR development.
Main Methods:
- 263 patients with positive patch tests to the GIRDCA standard series were recruited.
- Patch test readings were performed on days 2, 3, and every 2nd/3rd day thereafter until reaction resolution.
- Multivariate stepwise logistic regression analysis was used to identify risk factors.
Main Results:
- LLAPTR occurred in 17.9% of all reactions.
- Kathon CG was the most frequent cause of LLAPTR (76.1% of LLAPTR cases), with a mean reaction duration of 25.4 days.
- Key risk factors for LLAPTR included Kathon CG sensitivity, atopy, and strong initial patch test reactions.
Conclusions:
- LLAPTR are a significant finding in patch testing.
- Kathon CG sensitivity is the primary risk factor for LLAPTR.
- Atopy and strong patch test reactions also contribute to the development of LLAPTR.