Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A standardized blood sampling scheme in quantitative FDG-PET studies.

M Bentourkia1, A Bol, A Ivanoiu

  • 1Positron Tomography Laboratory, University of Louvain, Louvain-la-Neuve, Belgium.

IEEE Transactions on Medical Imaging
|July 23, 1999
PubMed
Summary

Accurate brain glucose metabolism (rCMRGlc) measurement using PET scans is possible with fewer arterial blood samples. A new fitting technique accurately defines the input curve, simplifying the process for researchers studying brain function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Poliomyelitis-like syndrome with matching magnetic resonance features in a case of Lyme neuroborreliosis.

BMJ case reports·2025
Same author

Poliomyelitis-like syndrome with matching magnetic resonance features in a case of Lyme neuroborreliosis.

BMJ case reports·2025
Same author

Progress in the Treatment of Alzheimer's Disease Is Needed - Position Statement of European Alzheimer's Disease Consortium (EADC) Investigators.

The journal of prevention of Alzheimer's disease·2024
Same author

Manganese-rhodium nanoparticles: Adsorption on titanium oxide surfaces and catalyst for syngas reactions.

The Journal of chemical physics·2024
Same author

Case of Susac's syndrome initially diagnosed as multiple sclerosis.

Journal francais d'ophtalmologie·2020
Same author

The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter.

Molecular psychiatry·2015

Area of Science:

  • Neuroimaging
  • Metabolic Research
  • Positron Emission Tomography (PET)

Background:

  • Quantitative estimation of brain glucose metabolism (rCMRGlc) via PET requires precise arterial input curves.
  • Traditional methods necessitate frequent arterial blood sampling (≤5s intervals) to capture peak radioactivity.

Purpose of the Study:

  • To develop and validate a standardized, reduced-sampling method for accurately defining the arterial input curve for rCMRGlc quantification.
  • To assess the consistency of rCMRGlc values derived from fitted versus measured input curves.

Main Methods:

  • A standardized 13-time-point sampling scheme was implemented.
  • The standardized input curve was fitted using polynomial functions (rising phase) and spectral analysis (decreasing phase).
  • rCMRGlc was calculated in 32 regions of interest in 20 volunteers using measured, standardized, and fitted input curves.

Related Experiment Videos

Main Results:

  • The standardized input curve accurately defined the radioactivity delivery.
  • rCMRGlc estimations using the fitted input curve showed minimal relative error (1-2%) compared to measured curves.
  • The input-curve-fitting technique proved robust, independent of peak time occurrence.

Conclusions:

  • A reduced arterial blood sampling scheme with input curve fitting provides accurate rCMRGlc quantification.
  • This technique simplifies the input curve determination process in PET studies of brain metabolism.
  • The method enhances the feasibility of studying brain glucose metabolism with less invasive procedures.