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Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis
V Borelli1, E Banfi, M G Perrotta
1Dipartimento di Fisiologia e Patologia, Università di Trieste, 34127 Trieste, Italy.
Infection and Immunity
|July 23, 1999
Abstract:
We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium.