Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models

Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens.

Immunology today·2014

Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment.

The Journal of experimental medicine·2001

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

Immunity·2001

A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.

The Journal of experimental medicine·2001

Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cells.

Immunology and cell biology·2001

Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-alpha and TNF gene-targeted mice.

Developmental immunology·2001

A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.

American journal of human genetics·2026

CanVar-UK: A collaborative platform for germline interpretation in cancer susceptibility genes.

American journal of human genetics·2026

Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults.

American journal of human genetics·2026

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as a candidate gene modulating risk for melanoma and nevi via RAS activation.

American journal of human genetics·2026

Monoallelic loss-of-function variants in ZNF536 are associated with a neurodevelopmental disorder with prominent behavioral features.

American journal of human genetics·2026

Beyond exons: Linking noncoding heritability and polygenicity across complex human traits and disorders.

American journal of human genetics·2026

Discovery of JH-XIII-05-01, a First-in-Class Dual IRAK1/IRAK4 Degrader for MYD88 Mutant Lymphomas.

ACS medicinal chemistry letters·2026

Immunological profiles of natural killer cells and their subpopulations in overweight and obesity class-I individuals stratified by two-dimensional categories of lipid profiles and body mass index.

Biomedical reports·2026

Childhood adversity and autoimmune diseases: global research landscape, immune-related hotspots, and emerging trends from a bibliometric analysis of three databases.

Frontiers in immunology·2026

Case Report: Single-cell transcriptomic profiling of a pediatric ALK-negative gastric inflammatory myofibroblastic tumor.

Frontiers in immunology·2026

Psychological distress differentiates subjective health within a vulnerable subgroup of patients with immune-mediated inflammatory diseases.

Frontiers in psychology·2026

Inflammatory Bowel Disease in Kazakhstan: Phenotypes, Disease Activity, and Treatment Patterns from a National Registry.

Journal of clinical medicine·2026

Related Experiment Videos

Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and

Related Concept Videos

Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens.

Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment.

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.

Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cells.

Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-alpha and TNF gene-targeted mice.

A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.

CanVar-UK: A collaborative platform for germline interpretation in cancer susceptibility genes.

Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults.

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as a candidate gene modulating risk for melanoma and nevi via RAS activation.

Monoallelic loss-of-function variants in ZNF536 are associated with a neurodevelopmental disorder with prominent behavioral features.

Beyond exons: Linking noncoding heritability and polygenicity across complex human traits and disorders.

Discovery of JH-XIII-05-01, a First-in-Class Dual IRAK1/IRAK4 Degrader for MYD88 Mutant Lymphomas.

Immunological profiles of natural killer cells and their subpopulations in overweight and obesity class-I individuals stratified by two-dimensional categories of lipid profiles and body mass index.

Childhood adversity and autoimmune diseases: global research landscape, immune-related hotspots, and emerging trends from a bibliometric analysis of three databases.

Case Report: Single-cell transcriptomic profiling of a pediatric ALK-negative gastric inflammatory myofibroblastic tumor.

Psychological distress differentiates subjective health within a vulnerable subgroup of patients with immune-mediated inflammatory diseases.

Inflammatory Bowel Disease in Kazakhstan: Phenotypes, Disease Activity, and Treatment Patterns from a National Registry.

Related Experiment Videos

Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and...

Related Concept Videos

Related Articles

Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and