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Related Experiment Videos

Apoptosis and the skin.

Y Teraki1, T Shiohara

  • 1Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.

European Journal of Dermatology : EJD
|July 27, 1999
PubMed
Summary
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Apoptosis, a regulated cell death, is crucial for maintaining skin homeostasis and its dysregulation contributes to various skin diseases. Understanding apoptosis mechanisms is key to developing treatments for skin conditions.

Area of Science:

  • Cell Biology
  • Dermatology
  • Immunology

Background:

  • Homeostasis in multicellular organisms relies on balancing cell proliferation and death.
  • Apoptosis, or programmed cell death, is a physiological process involving specific morphological and biochemical changes.
  • Apoptosis is implicated in the pathogenesis of numerous skin diseases.

Purpose of the Study:

  • To review the fundamental concepts of apoptosis.
  • To elucidate the role of apoptosis in skin homeostasis.
  • To discuss the relevance of apoptosis in the context of various skin diseases.

Main Methods:

  • Literature review of apoptosis mechanisms.
  • Analysis of apoptosis's role in skin physiology.
  • Examination of apoptosis in dermatological conditions.

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Main Results:

  • Apoptosis is characterized by cell shrinkage, chromatin condensation, and DNA fragmentation.
  • Key regulators like Bcl-2 and signaling pathways such as Fas-FasL and perforin-granzyme B are involved.
  • Apoptotic keratinocytes (Civatte bodies) are observed in lichenoid tissue reactions.

Conclusions:

  • Apoptosis is essential for skin homeostasis, including keratinocyte differentiation and the hair cycle.
  • Dysregulation of apoptosis, involving factors like Bcl-2 and FasL, impacts skin tumor progression and immune evasion.
  • This review highlights the critical role of apoptosis in skin health and disease.