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Polymorphisms of HLA-DM genes in Japanese patients with psoriasis vulgaris

H Saeki1, H Nakagawa, A Asahina

  • 1Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113, Japan.

The British Journal of Dermatology
|July 27, 1999
PubMed

Insights

Genetic variations in HLA-DM genes were analyzed in Japanese psoriasis vulgaris patients. Frequencies of specific HLA-DM alleles showed differences, but these were not statistically significant after correction, suggesting a minor role in psoriasis development.

Area of Science:

  • Immunogenetics
  • Dermatology
  • Molecular Biology

Background:

  • Psoriasis vulgaris is a chronic inflammatory skin disease with complex genetic components.
  • Human Leukocyte Antigen (HLA) genes are known to be involved in immune responses and autoimmune diseases.
  • Previous research suggested a role for HLA-C molecules in the pathogenesis of psoriasis vulgaris.

Purpose of the Study:

  • To investigate the association between polymorphisms in Human Leukocyte Antigen - DM (HLA-DM) genes and psoriasis vulgaris in a Japanese population.
  • To determine if specific HLA-DM alleles are risk factors or protective factors for developing psoriasis vulgaris.

Main Methods:

  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was employed.
  • Analysis included 85 unrelated Japanese patients diagnosed with psoriasis vulgaris and 52 healthy Japanese controls.
  • Genotyping focused on polymorphisms within the HLA-DM genes.

Main Results:

  • A decreased frequency of the DMA*0101 allele (79% in patients vs. 89% in controls, P < 0.05) and an increased frequency of the DMA*0102 allele (20% in patients vs. 11% in controls, P < 0.05) were observed in patients.
  • These observed differences in allele frequencies did not remain statistically significant after correcting for multiple comparisons (Pc > 0.05).

Conclusions:

  • The study found no statistically significant association between HLA-DM gene polymorphisms and psoriasis vulgaris in the Japanese cohort after correcting for multiple comparisons.
  • These findings suggest that HLA-DM genes may play a less significant role in the development of psoriasis vulgaris compared to HLA-C molecules.

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