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Pacinian collagenoma.

P Pillay1, A S Essa, R Chetty

  • 1Department of Pathology, University of Natal School of Medicine, Private Bag 7, Congella 4013, Durban, South Africa. pillayp11@med.und.ac.za

The British Journal of Dermatology
|July 27, 1999
PubMed
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This study describes a rare histological variant of collagenoma, a benign skin tumor. The collagenoma presented with a unique "onion skin" appearance under microscopic examination.

Area of Science:

  • Dermatopathology
  • Histology
  • Oncology

Background:

  • Collagenomas are benign tumors of fibroblasts, characterized by an overproduction of collagen.
  • Histological variants of collagenoma are uncommon, posing diagnostic challenges.
  • Accurate histological classification is crucial for differentiating benign lesions from other soft tissue tumors.

Observation:

  • A 36-year-old woman presented with a palpable mass in the left hypothenar eminence.
  • Histological examination revealed a well-circumscribed lesion with paucicellular collagen fibers arranged in concentric lamellae, resembling an 'onion skin' pattern.
  • The epidermis was thin, with an epidermal collarette at the lateral borders. No inflammatory cells or xanthoma cells were observed.

Findings:

  • The lesion demonstrated positivity for collagen stains, reticulin, and CD34.

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  • The characteristic 'onion skin' morphology and immunophenotype distinguish this variant from other fibrotic lesions.
  • Absence of inflammation and xanthoma cells further supports its classification as a distinct collagenoma subtype.

    • Implications:

    • This case highlights an unusual histological presentation of collagenoma, expanding the spectrum of benign fibrous tumors.
    • Recognition of this specific histological pattern and immunophenotype is essential for accurate diagnosis and to avoid misclassification.
    • Understanding rare variants of collagenoma contributes to the comprehensive knowledge of soft tissue neoplasms.