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Association between hyperhomocysteinaemia and hypertension in Sri Lankans
S Mendis1, S B Athauda, M Naser
1Department of Medicine, Faculty of Medicine, Peradinya, Sri Lanka.
Insights
High homocysteine levels are linked to hypertension in Sri Lankan patients. This study found elevated homocysteine, cysteine, and cysteinylglycine in hypertensive individuals, indicating a significant risk factor.
Area of Science:
- Cardiovascular Research
- Metabolic Health
- Clinical Biochemistry
Background:
- Essential hypertension is a prevalent cardiovascular condition.
- Homocysteine and its metabolites play roles in vascular health.
- Understanding risk factors for hypertension in diverse populations is crucial.
Purpose of the Study:
- To investigate the association between homocysteine and its metabolites with essential hypertension.
- To determine if elevated homocysteine levels are a risk factor for hypertension in Sri Lankan adults.
Main Methods:
- Serum concentrations of homocysteine, cysteine, cysteinylglycine, and glutathione were measured.
- A cohort of 86 Sri Lankan patients with essential hypertension was compared to an age- and sex-matched control group.
Main Results:
- Patients with essential hypertension exhibited significantly higher mean serum concentrations of homocysteine, cysteine, and cysteinylglycine compared to controls.
- A mean serum homocysteine concentration above 18 mumol/l was associated with an odds ratio of 2.8 for hypertension.
Conclusions:
- Hyperhomocysteinaemia is identified as a significant risk factor for hypertension among Sri Lankans.
- Elevated homocysteine levels can increase the risk of developing hypertension by threefold.
Abstract:
This study examined the relationship between homocysteine and its metabolites, and hypertension in a cohort of Sri Lankan patients with essential hypertension. Serum homocysteine, cysteine, cysteinylglycine and glutathione were measured in 86 patients with a diagnosis of essential hypertension and compared with those of an age- and sex-matched control group. Patients with hypertension had significantly higher mean serum concentrations of homocysteine, cysteine and cysteinylglycine. The odds ratio for hypertension for those with a mean serum homocysteine concentration above 18 mumol/l was 2.8. Hyperhomocysteinaemia is a risk factor for hypertension in Sri Lankans and can lead to a threefold increase in risk.