Related Experiment Video

Updated: Aug 3, 2026

Experimental Human Pneumococcal Carriage
07:47

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

[The Pneumococcus Observatory of the Central Region, from June 1, 1997 to May 31, 1998]

B Cattier1, D Lecocq, R Levillain

  • 1Laboratoire de Microbiologie, CHU Bretonneau, Tours, France.

Pathologie-Biologie
|July 27, 1999
PubMed

Insights

A study of 714 pneumococcus strains found 47.3% were penicillin-resistant (PRSP), with higher rates in children. Most PRSP strains showed intermediate resistance to penicillin G, with some resistance to amoxicillin and cefotaxime.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Epidemiology

Context:

  • Surveillance of Streptococcus pneumoniae (pneumococcus) is crucial for public health.
  • Antimicrobial resistance in pneumococcus poses a significant treatment challenge.
  • Understanding regional resistance patterns informs clinical practice and public health strategies.

Purpose:

  • To assess the prevalence of penicillin-resistant Streptococcus pneumoniae (PRSP) in a specific region.
  • To characterize the antimicrobial susceptibility profiles of PRSP strains.
  • To identify common pneumococcal serotypes associated with resistance.

Summary:

  • A total of 714 pneumococcus strains were analyzed from June 1997 to May 1998.
  • 47.3% of strains were identified as PRSP, with higher proportions in children (57.8%) compared to adults (41%).
  • Of the PRSP strains studied, 27.7% were resistant and 72.3% intermediate to penicillin G; low-level resistance to amoxicillin and cefotaxime was also observed. Serotypes 23 and 14 were most common.

Impact:

  • Provides essential epidemiological data on pneumococcal resistance in the region.
  • Highlights the need for ongoing monitoring of antimicrobial susceptibility patterns.
  • Informs treatment guidelines and potential vaccine strategies based on prevalent serotypes.

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