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The enteric nervous system: a second brain.

M D Gershon1

  • 1Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, USA.

Hospital Practice (1995)
|July 27, 1999
PubMed
Summary
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The enteric nervous system (ENS) is a complex brain, not just ganglia. Research is advancing our understanding of ENS function for better treatment of functional bowel diseases.

Area of Science:

  • Neuroscience
  • Gastroenterology

Background:

  • The enteric nervous system (ENS) was historically viewed as a simple collection of relay ganglia.
  • Emerging evidence reclassifies the ENS as a complex, integrative brain within the gastrointestinal tract.

Purpose of the Study:

  • To highlight the evolving understanding of the ENS as a distinct neural system.
  • To underscore the ongoing research efforts aimed at linking ENS neural activity to complex gut functions.

Main Methods:

  • Review of current neuroscience and gastroenterology research.
  • Analysis of progress in correlating neuronal activity with physiological gut behaviors.

Main Results:

  • The ENS is now recognized as a sophisticated neural network with intrinsic processing capabilities.

Related Experiment Videos

  • Significant progress is being made in understanding the relationship between individual neuron activity and gut motility and secretion.

    • Conclusions:

    • The ENS functions as an independent 'brain' within the gut.
    • Continued research promises rapid advancements in managing functional bowel diseases through a deeper understanding of the ENS.