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Liver transplantation with monosegments.

P Srinivasan1, H Vilca-Melendez, P Muiesan

  • 1Institute of Liver Studies, Kings College Hospital, London, United Kingdom.

Surgery
|July 27, 1999
PubMed
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Monosegment liver transplantation using segment III grafts offers a viable solution for infants with liver failure. This technique achieved an 83.3% survival rate in a small cohort of neonates.

Area of Science:

  • Hepatobiliary surgery
  • Pediatric transplantation
  • Organ donor management

Background:

  • Donor liver shortage necessitates innovative pediatric transplantation strategies.
  • Neonatal liver transplantation is challenging due to recipient size limitations.
  • Segment III liver grafts (left lateral segment) can be utilized for infant recipients.

Purpose of the Study:

  • To evaluate the efficacy and outcomes of monosegment (segment III) liver transplantation in neonates.
  • To assess the feasibility of using reduced liver grafts for infant liver failure.

Main Methods:

  • Retrospective analysis of 6 neonatal liver transplantations using monosegment (segment III) grafts.
  • Donor livers were reduced to a left lateral segment, with segment II resected.

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  • Patients received grafts between October 1989 and March 1998.

    • Main Results:

    • Overall graft and patient survival rate was 83.3%.
    • Five of six patients survived with good graft function at a mean follow-up of 30.4 months.
    • No vascular or biliary complications were observed in survivors.

    Conclusions:

    • Monosegment liver transplantation with segment III is a satisfactory option for neonates with liver failure.
    • This technique expands donor options for infant liver transplantation.