Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cocaine-induced oscillation is conditionable.

B J Kucinski1, S M Antelman, A R Caggiula

  • 1Department of Psychology, University of Pittsburgh, PA 15213, USA.

Pharmacology, Biochemistry, and Behavior
|July 27, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response: Use of the WISCI-II score in assessing outcome of intensive robot-assisted gait training in spinal cord injury.

Spinal cord·2024
Same author

Reverse supply chain practices for construction and demolition waste in the Brazilian Amazon: a multi-stakeholder view.

Journal of material cycles and waste management·2023
Same author

Investigation of interfacial strength in nacre-mimicking tungsten heavy alloys for nuclear fusion applications.

Scientific reports·2023
Same author

Hartmann's procedure versus intersphincteric abdominoperineal excision (HiP Study): a multicentre prospective cohort study.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

A new mechanism for void-cascade interaction from nondestructive depth-resolved atomic-scale measurements of ion irradiation-induced defects in Fe.

Science advances·2020
Same author

Early anastomotic complications in colorectal surgery: a systematic review of techniques for endoscopic salvage.

Surgical endoscopy·2019

Cocaine (COC) induced oscillation, a phenomenon of alternating drug effects, can be conditioned. A conditioned stimulus previously paired with COC successfully induced both sensitization and oscillation.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Sensitization to cocaine (COC) can exhibit oscillation, characterized by alternating attenuations and reinstatements of its effects with repeated administration.
  • Conditioning plays a role in cocaine-induced sensitization, prompting investigation into whether oscillation is also conditionable.

Purpose of the Study:

  • To determine if cocaine-induced oscillation, following initial sensitization, can be conditioned.
  • To investigate the role of conditioned stimuli in sustaining or inducing cocaine-induced oscillation and sensitization.

Main Methods:

  • Utilized shock-induced hypoalgesia (paw withdrawal latency) as the primary endpoint.
  • Administered cocaine (12 mg/kg, IP) at weekly intervals to induce sensitization and oscillation.

Related Experiment Videos

  • Paired a distinctive environmental conditioned stimulus (CS) with cocaine administration in Experiments 1 and 2.

    • Main Results:

    • A conditioned stimulus (CS) previously paired with cocaine could substitute for the final cocaine injection, sustaining the oscillatory effect.
    • A previously established CS successfully substituted for all cocaine injections, inducing initial sensitization followed by oscillation.

    Conclusions:

    • Cocaine-induced oscillation demonstrates conditionability, similar to cocaine-induced sensitization.
    • These findings suggest that learned associations (conditioning) can influence the complex patterns of drug effects, including oscillation.