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Related Experiment Videos

Cocaine-induced oscillation is conditionable.

B J Kucinski1, S M Antelman, A R Caggiula

  • 1Department of Psychology, University of Pittsburgh, PA 15213, USA.

Pharmacology, Biochemistry, and Behavior
|July 27, 1999
PubMed
Summary
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Cocaine (COC) induced oscillation, a phenomenon of alternating drug effects, can be conditioned. A conditioned stimulus previously paired with COC successfully induced both sensitization and oscillation.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Sensitization to cocaine (COC) can exhibit oscillation, characterized by alternating attenuations and reinstatements of its effects with repeated administration.
  • Conditioning plays a role in cocaine-induced sensitization, prompting investigation into whether oscillation is also conditionable.

Purpose of the Study:

  • To determine if cocaine-induced oscillation, following initial sensitization, can be conditioned.
  • To investigate the role of conditioned stimuli in sustaining or inducing cocaine-induced oscillation and sensitization.

Main Methods:

  • Utilized shock-induced hypoalgesia (paw withdrawal latency) as the primary endpoint.
  • Administered cocaine (12 mg/kg, IP) at weekly intervals to induce sensitization and oscillation.

Related Experiment Videos

  • Paired a distinctive environmental conditioned stimulus (CS) with cocaine administration in Experiments 1 and 2.

    • Main Results:

    • A conditioned stimulus (CS) previously paired with cocaine could substitute for the final cocaine injection, sustaining the oscillatory effect.
    • A previously established CS successfully substituted for all cocaine injections, inducing initial sensitization followed by oscillation.

    Conclusions:

    • Cocaine-induced oscillation demonstrates conditionability, similar to cocaine-induced sensitization.
    • These findings suggest that learned associations (conditioning) can influence the complex patterns of drug effects, including oscillation.