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Related Experiment Videos

Steroidogenic factor 1 (SF-1) is essential for endocrine development and function.

X Luo1, Y Ikeda, D Lala

  • 1Department of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235, USA.

The Journal of Steroid Biochemistry and Molecular Biology
|July 27, 1999
PubMed
Summary
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Steroidogenic factor 1 (SF-1) is crucial for embryonic development of adrenal and gonadal organs. SF-1 regulates reproductive functions across the hypothalamic-pituitary-gonadal axis.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Molecular Biology

Background:

  • Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor.
  • SF-1 regulates tissue-specific expression of cytochrome P450 steroid hydroxylases.

Purpose of the Study:

  • To review experiments defining the essential roles of SF-1 in endocrine development.
  • To highlight future research areas for SF-1.

Main Methods:

  • Analysis of SF-1 expression during mouse embryological development.
  • Analysis of SF-1 knockout mice.

Main Results:

  • SF-1 knockout mice exhibited adrenal and gonadal agenesis.
  • SF-1 knockout mice showed male-to-female sex reversal and died from adrenocortical insufficiency.

Related Experiment Videos

  • SF-1 regulates reproductive function at all three levels of the hypothalamic-pituitary gonadal axis.

    • Conclusions:

    • SF-1 is essential for embryonic survival of primary steroidogenic organs.
    • SF-1 plays a critical role in regulating reproductive functions throughout the hypothalamic-pituitary-gonadal axis.