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A case of thrombopoietin-producing ovarian carcinoma confirmed by immunohistochemistry
1Department of Obstetrics and Gynecology, Handa City Hospital, Handa, 475-8599, Japan.
Gynecologic Oncology
|July 27, 1999
Abstract:
A case of ovarian carcinoma with thrombopoietin production is reported. A 49-year-old Japanese woman had serous cystadenocarcinoma of the right ovary with peritoneal spread. The platelet count was elevated to 432 x 10(9)/L. Enzyme-linked immunosorbent assay of the serum demonstrated remarkably high levels of thrombopoietin (2.96 fmol/ml). Immunohistochemical examination using an antibody specific for thrombopoietin revealed positive staining in the carcinoma cells, confirming thrombopoietin production.