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[Human adaptive phenotypes in physiology and medicine]
1State Research Centre of RF, Institute of Biomedical Problems, Moscow.
Uspekhi Fiziologicheskikh Nauk
|July 27, 1999
Summary
This study defines adaptive phenotypes, a stable complex of genetic and phenotypic traits, crucial for understanding individual health and disease. Utilizing genetic and clinical methods, this approach aids in identifying hereditary parameters for personalized medicine and professional selection.
Area of Science:
- General biology
- Human genetics
- Physiology
Context:
- The study of genetic syndromes and their associated pathological and physiological features has grown significantly.
- Understanding individual responses requires considering genetic specificity and constitutional factors.
Purpose:
- To define adaptive phenotypes and summarize challenges in this field.
- To propose the term 'adaptophenotype' for a stable complex of genetic and phenotypic characteristics.
- To highlight the utility of an individual-constitutional approach in medicine and physiology.
Summary:
- An adaptophenotype integrates genetic and phenotypic characteristics, determinable through clinical, physiological, genealogical, dermatoglyphic, and genetic marker analyses.
- This concept encompasses a wide spectrum of human functioning, including somatic disorders, psychopathology, and physiological/behavioral issues.
- Genetic approaches can reveal both manifest and latent hereditary parameters, valuable for applications like professional selection.
Impact:
- Facilitates a deeper understanding of genetic influences on health and disease.
- Provides a framework for personalized medicine and tailored health interventions.
- Supports the identification of predispositions and latent characteristics for proactive health management and career guidance.