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Updated: Aug 8, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
[A clinico-immunological study in recurrent mild craniocerebral trauma in the acute period]
Abstract:
Comparative clinical (X-ray study, computed tomography, echoencephalography, electroencephalography, electrocardiography, examination of the fundus of the eye, lumbar puncture) and immunological (examination of cellular and humoral immunities, neurosensitization) studies were conducted in 98 patients with the first mild brain injury and 92 with repeated injury. Clinical and immunological parameters became worse in patients with repeated brain injury at week 3, which shows the development of autoimmune autoaggressive reactions in the sensitized body. These patients should be referred to as a risk group of disease progression and they should be given immunomodulating therapy.
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