Related Experiment Videos
Physico-chemical characterization of meglumine antimoniate
C Demicheli1, T L de Figueiredo, S Carvalho
1Departamento de Química, Universidade Federal de Minas Gerais, Brasil.
Abstract:
The leishmanicidal drug, meglumine antimoniate (MA), has been synthesized by the reaction of antimony oxyhydrated and N-methyl glucamine. Infrared and solid state NMR 13C analysis of MA and the ligand strongly suggests that antimony binds to N-methyl glucamine through the oxygen of C-3 carbon. Potentiometric titration indicated that, between pH 4.5 and 7.5, MA exists in the zwitterionic form.