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Alkylating agents from sugars. Alkyl hexopyranoside derivatives as carrier systems for chlorambucil
F Iglesias-Guerra1, J I Candela, J Bautista
1Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Spain.
Carbohydrate Research
|July 27, 1999
Abstract:
Chlorambucil derivatives involving alkyl 2-aminodeoxy sugars have been synthesized in good yield by coupling the chlorambucil moiety to positions C-2 or C-3 of the sugar, directly or via a spacer. The starting material was easily available from 2-acetamido-2-deoxy-D-glucose. The final compounds were tested for cytotoxicity, and some of those that presented the best results were studied for inhibition of cell proliferation.