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Malignant pleural mesothelioma: a problematic review
T L Moskal1, J D Urschel, T M Anderson
1Department of Thoracic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Surgical Oncology
|July 27, 1999
Summary
Malignant pleural mesothelioma, a rare cancer, requires further research due to poor treatment outcomes. Optimal management involves multimodality therapy, including surgery and adjuvant treatments, with ongoing investigations into improved staging and novel therapies.
Area of Science:
- Oncology
- Thoracic Surgery
- Pathology
Background:
- Malignant pleural mesothelioma is a rare and aggressive tumor.
- Limited understanding and poor treatment results necessitate ongoing research.
- Diagnosis, staging, and natural history present significant challenges.
Purpose of the Study:
- To review clinicopathologic aspects of malignant pleural mesothelioma.
- To address problematic issues in diagnosis, staging, and treatment.
- To highlight areas for future research and development.
Main Methods:
- Clinicopathologic review of malignant pleural mesothelioma.
- Analysis of current diagnostic and staging methodologies.
- Evaluation of existing and experimental treatment strategies.
Main Results:
- Multimodality treatment (surgery + adjuvant therapy) is the current optimal approach.
- Significant controversies persist regarding optimal treatment protocols.
- Improved staging and novel therapies are crucial for better outcomes.
Conclusions:
- Malignant pleural mesothelioma remains an area of active research.
- Future advancements in staging and experimental therapies are expected.
- Centralization of patient care at expert centers may improve disease management.