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Molecular angiogenesis
1Department of Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. klagsbrun@a1.tch.harvard.edu.
Chemistry & Biology
|July 28, 1999
Abstract:
New insights into the mechanisms by which blood vessels develop (angiogenesis) have been gained recently, primarily by the identification of factors that inhibit and promote this process. Angiogenesis-stimulating factors are being used to promote growth of new blood vessels in ischemic disease. In contrast, anti-angiogenesis factors are being used as inhibitors of neovascularization to control tumor growth and metastasis.