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Recruitment of proteins to modulate protein-protein interactions
1Center for Cancer Research, Departments of Biology and Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. junliu@mit.edu
Chemistry & Biology
|July 28, 1999
Abstract:
The use of a 'borrowed' protein surface to either enhance or inhibit the interaction of a small ligand with its protein target has been reported recently. This approach represents a general method for modulating protein-protein interactions and may find many applications in both biology and medicine.