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Osteoarthritis caused by Neocosmospora vasinfecta
Medical Mycology
|July 28, 1999
Abstract:
We report the case of a patient who developed an ankle osteoarthritis due to the Ascomycete Neocosmospora vasinfecta, following accidental multiple trauma to his legs in whilst in Africa. Antifungal susceptibility testing was performed. Despite a low amphotericin B minimal inhibitory concentration, parenteral antifungal therapy failed and amputation was required to resolve the osteoarthritis. Possible reasons for the failure of this antifungal treatment are examined.
Insights
A rare fungal infection caused Neocosmospora vasinfecta osteoarthritis in a patient
Area of Science:
- Mycology
- Infectious Diseases
- Orthopedics
Background:
- Osteoarthritis can arise from various causes, including infections.
- Traumatic injuries can predispose individuals to secondary complications.
Observation:
- A patient developed ankle osteoarthritis after severe leg trauma in Africa.
- The osteoarthritis was attributed to infection by the fungus Neocosmospora vasinfecta.
Findings:
- Antifungal susceptibility testing showed a low minimal inhibitory concentration for amphotericin B.
- Despite this, parenteral antifungal therapy was ineffective.
- Amputation was ultimately necessary to treat the fungal osteoarthritis.
Implications:
- This case highlights the potential for Neocosmospora vasinfecta to cause invasive infections.
- It underscores challenges in treating deep-seated fungal osteoarthritis, even with seemingly susceptible organisms.
- Further research into treatment strategies for such infections is warranted.