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GaAs (904-nm) laser radiation does not affect muscle regeneration in mouse skeletal muscle
N M Oliveira1, N A Parizzotto, T F Salvini
1Master Physical Therapy Program, Universidade Federal de São Carlos, 13565-905 São Carlos, SP, Brazil.
Background And Objective:
We evaluated the effect of GaAs (904-nm) laser, applied directly to the skin of injured muscle, in muscle regeneration.
Study Design/Material And Methods:
Muscle injury was induced in the Tibialis anterior (TA) muscle by ACL myotoxin (5 mg/kg). Two groups were irradiated with doses of 3 (n = 8) and 10 J/cm(2)(n = 8). GaAs laser (power 1.5 mW, intensity 7.5 mW/cm(2), spot 0.2 cm(2)) was applied daily for five days. Contralateral TA received a sham procedure.
Results:
Similar morphological aspects were found in both laser irradiated and sham muscles. No differences were found in the muscle weight, but animals irradiated with 10 J/cm(2) showed a significant gain of body weight (P = 0.002).
Conclusions:
Doses of 3 and 10 J/cm(2) of GaAs laser were not efficient to promote significant morphological changes in the regenerated skeletal muscle, but the dose of 10 J/cm(2) promoted significant gain of body weight.