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Related Experiment Videos

[Multiple myeloma presenting as massive ascites].

M Shimizu1, H Tsurumi, T Hara

  • 1First Department of Internal Medicine, Gifu University School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|July 28, 1999
PubMed
Summary
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This case study details a rare instance of multiple myeloma causing massive ascites due to peritoneal involvement. Treatment with melphalan and prednisolone effectively reduced ascites and myeloma markers.

Area of Science:

  • Hematology
  • Oncology
  • Internal Medicine

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Ascites is an uncommon but serious complication.

Observation:

  • An 80-year-old woman presented with massive ascites.
  • Laboratory results revealed elevated IgA, CA125, and Interleukin-6 (IL-6).
  • Ascitic fluid contained atypical plasma cells and elevated IgA and IL-6.

Findings:

  • Diagnosis of IgA lambda multiple myeloma with peritoneal involvement.
  • Atypical plasma cells in bone marrow aspirate (32.7%).
  • Monoclonal IgA lambda detected in serum and BJP lambda in urine.

Implications:

  • Highlights peritoneal involvement as a rare presentation of multiple myeloma.

Related Experiment Videos

  • Demonstrates the efficacy of melphalan and prednisolone chemotherapy.
  • Suggests IL-6 and CA125 as potential biomarkers for peritoneal multiple myeloma.