Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chiral compounds and their pharmacologic effects].

A Slováková1, A J Hutt

  • 1Katedra chemickej teórie lieciv, Farmaceutická Fakulta Univerzity Komenského, Bratislava.

Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti
|July 28, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Connectivity of the anterior insula differentiates participants with first-episode schizophrenia spectrum disorders from controls: a machine-learning study.

Psychological medicine·2016
Same author

Psychiatrist's adherence: a new factor in relapse prevention of schizophrenia. A randomized controlled study on relapse control through telemedicine system.

Journal of psychiatric and mental health nursing·2015
Same author

[Treatment options in sarcoidosis].

Casopis lekaru ceskych·2008
Same author

[Blockers of beta-adrenergic receptors--a group of chiral agents stereoselective synthesis of beta-blockers].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2005
Same author

[Chiral switch: pure enantiomers of drugs instead of racemic mixtures].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2005
Same author

Disposition of flurbiprofen in man: influence of stereochemistry and age.

Xenobiotica; the fate of foreign compounds in biological systems·2003
Same journal

Foot mycoses - treatment with over-the-counter preparations based on clinical recommendations.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2026
Same journal

Travel first aid kit 2026.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2026
Same journal

Tirzepatide.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2026
Same journal

Atrasentan: new molecule in the therapy of IgA nephropathy and other glomerulopathies.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2026
Same journal

Pulmonary delivery of monoclonal antibodies: challenges, limitations,and modern formulation strategies.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2026
Same journal

Pharmaceutical care in self-medication: ABC/VED analysis of over-the-counter antiallergic medicines.

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti·2026
See all related articles

Understanding drug stereochemistry is crucial. Analyzing individual drug enantiomers, not just racemates, can enhance safety, efficacy, and reveal new therapeutic uses.

Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Drug Development

Context:

  • Current drug development often overlooks stereochemistry, treating racemic mixtures as single entities.
  • Limited data exists on the distinct pharmacological, toxicological, and pharmacokinetic profiles of individual enantiomers.
  • Factors like age, health, sex, and genetics can significantly alter drug response.

Purpose:

  • To highlight the significance of stereochemistry in drug action.
  • To review advancements in chiral pharmacology and selective drug effects.
  • To advocate for individual enantiomer assessment over racemic mixtures.

Summary:

  • Drug stereochemistry is vital; racemates (mixtures of enantiomers) require individual evaluation.
  • Assessing enantiomers separately is necessary due to varying biological effects.

Related Experiment Videos

  • Case-by-case analysis is essential, as no universal solution exists for racemates versus enantiomers.

    • Impact:

    • Individual enantiomer testing can uncover novel drug indications.
    • Optimizing drug use by considering stereochemistry improves clinical outcomes.
    • Enhanced understanding of enantiomers increases drug safety and therapeutic efficacy.